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Home - Products - GPCR/G Protein - Chemokine Receptor - BI 6901

BI 6901

CAS No. 2040401-92-9

BI 6901( BI6901 )

Catalog No. M13172 CAS No. 2040401-92-9

BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BI 6901
  • Note
    Research use only, not for human use.
  • Brief Description
    BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0.
  • Description
    BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0, shows high selectivity over other GPCRs; inhibits the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with pIC50 of 9.0, BI 6901 is efficacious in a murine model of DNFB contact hypersensitivity, inhibits DNFB stimulated inflammatory response in sensitized Balb-C mice.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Balb-C mice with a DNFB model of contact hypersensitivity.Dosage:100 mg/kg Administration:Intraperitoneal?injection Result:Had a inhibitory effect on the DNFB stimulated inflammatory response in sensitized Balb-c mice.
  • Synonyms
    BI6901
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2040401-92-9
  • Formula Weight
    453.561
  • Molecular Formula
    C23H27N5O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 160 mg/mL (352.76 mM)
  • SMILES
    O=S(C1=CC=CC2=C1C=CN2)(N[C@H](CCN3C(C#N)=CC=C3)C(N4CCC(C)CC4)=O)=O
  • Chemical Name
    N-[(2R)-4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Abeywardane A, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.
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